Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 6.825


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOSchr14_+_748152330.702.5e-03Click!
FOSBchr19_+_506630890.702.8e-03Click!
JUNDchr19_-_18253436-0.514.2e-02Click!
FOSL1chr11_-_654244360.467.1e-02Click!
JUNBchr19_+_127632850.371.6e-01Click!


Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_177378801 47.097 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr18_+_19706979 44.490 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_+_221955876 39.742 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr6_+_47774247 35.485 NM_153838
GPR115
G protein-coupled receptor 115
chr1_+_181421984 34.959 LAMC2
laminin, gamma 2
chr20_-_17487480 31.517 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr3_+_11153778 31.187 NM_001098213
HRH1
histamine receptor H1
chr21_+_29439768 31.162 C21orf7
chromosome 21 open reading frame 7
chr10_-_88720908 28.655 LOC100133190
hypothetical LOC100133190
chr12_+_13240868 28.345 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240987 28.010 EMP1
epithelial membrane protein 1
chr12_+_13240983 27.312 EMP1
epithelial membrane protein 1
chr3_-_152517204 26.833 NM_023915
GPR87
G protein-coupled receptor 87
chr7_+_116099648 26.442 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr1_+_181421796 25.377 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr5_+_150000394 24.869 NM_001109974
NM_007286
SYNPO

synaptopodin

chr1_+_181422016 23.444 LAMC2
laminin, gamma 2
chr9_+_102231616 23.337 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr8_+_22900863 22.706 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr10_+_24795465 21.753 KIAA1217
KIAA1217
chr10_+_24795446 21.331 KIAA1217
KIAA1217
chr18_+_59593591 21.114 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr8_-_38505331 20.925 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr9_-_90456824 20.803 NM_001100111
LOC286238
hypothetical protein LOC286238
chr14_-_104507862 20.375 AHNAK2
AHNAK nucleoprotein 2
chr11_-_65860450 19.966 NM_004292
RIN1
Ras and Rab interactor 1
chr1_-_94779727 19.815 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr6_+_31190505 19.355 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr12_-_51173238 18.768 NM_005554
KRT6A
keratin 6A
chr18_+_59295123 18.572 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr14_+_104218487 18.354


chr17_-_7962531 17.838 NM_021628
ALOXE3
arachidonate lipoxygenase 3
chr11_+_101488380 17.074 NM_001195045
YAP1
Yes-associated protein 1
chr3_+_57069508 16.777 NM_181727
SPATA12
spermatogenesis associated 12
chr15_+_38319326 16.760 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_154351082 16.695 NM_005572
NM_170707
NM_170708
LMNA


lamin A/C


chr9_-_129381086 16.355 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr17_-_36996611 16.325 NM_000526
KRT14
keratin 14
chr4_+_108965167 16.007 NM_001136258
SGMS2
sphingomyelin synthase 2
chr5_+_145297490 15.974 SH3RF2
SH3 domain containing ring finger 2
chr1_-_207891264 15.572 NM_001017402
LAMB3
laminin, beta 3
chr1_+_34993234 15.334 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr20_+_19903778 15.174 RIN2
Ras and Rab interactor 2
chr12_-_68369322 14.812 NM_152439
BEST3
bestrophin 3
chr1_-_36589744 14.754


chr1_-_108032645 14.560 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr1_+_27062215 14.425 NM_006142
SFN
stratifin
chr9_+_676640 13.972


chr17_+_21131940 13.847 NM_002756
MAP2K3
mitogen-activated protein kinase kinase 3
chr10_+_118177371 13.828 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr11_-_6298284 13.710 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr7_+_838663 13.578 NM_001130965
SUN1
Sad1 and UNC84 domain containing 1
chr6_-_138470160 13.458 NM_022121
PERP
PERP, TP53 apoptosis effector
chr2_+_113591940 13.457 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr19_+_43486640 13.373 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr6_-_152744143 13.325 SYNE1
spectrin repeat containing, nuclear envelope 1
chr16_+_56219802 13.252 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr12_+_10256682 13.094 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr1_-_205272619 13.006 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr6_-_152744022 12.919 SYNE1
spectrin repeat containing, nuclear envelope 1
chr3_-_150578103 12.911 TM4SF1
transmembrane 4 L six family member 1
chr4_-_115120251 12.905 NM_024590
ARSJ
arylsulfatase family, member J
chr4_+_183302105 12.872 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr11_-_119499188 12.836 TRIM29
tripartite motif containing 29
chr2_-_65447267 12.817 SPRED2
sprouty-related, EVH1 domain containing 2
chr3_-_11585264 12.603 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr1_+_154351200 12.552 LMNA
lamin A/C
chr19_-_52427698 12.417 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr7_+_28692122 12.411 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr3_-_150578207 12.297 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr2_+_73911477 12.245 STAMBP
STAM binding protein
chr3_-_150578148 12.239 TM4SF1
transmembrane 4 L six family member 1
chr1_+_24518501 12.180 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr1_-_151788341 12.142 NM_002960
S100A3
S100 calcium binding protein A3
chr1_+_154351162 12.129 LMNA
lamin A/C
chr18_+_50646616 12.080 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr12_-_56445653 12.020 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr14_+_51025604 12.016 NM_001042481
FRMD6
FERM domain containing 6
chr17_-_7962859 11.963 NM_001165960
ALOXE3
arachidonate lipoxygenase 3
chr3_-_150578023 11.807 TM4SF1
transmembrane 4 L six family member 1
chr2_-_65447370 11.513 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr15_-_38417564 11.334 C15orf52
chromosome 15 open reading frame 52
chr6_-_10527772 11.247 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chrX_+_99786044 11.245 SRPX2
sushi-repeat containing protein, X-linked 2
chr4_+_169989680 11.238 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr11_-_123353607 11.161 NM_001004474
OR10S1
olfactory receptor, family 10, subfamily S, member 1
chr20_-_35586366 11.161 NM_001167823
BLCAP
bladder cancer associated protein
chr11_-_117640166 11.128 MPZL2
myelin protein zero-like 2
chr7_-_104696678 11.087 NM_182691
SRPK2
SRSF protein kinase 2
chr17_-_37034288 11.054 NM_000422
KRT17
keratin 17
chr1_+_24518398 10.768 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chrX_+_99785818 10.663 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr3_-_48607596 10.567 NM_000094
COL7A1
collagen, type VII, alpha 1
chr5_+_147562531 10.560 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr17_-_37022465 10.477 NM_005557
KRT16
keratin 16
chr6_+_74462654 10.417 CD109
CD109 molecule
chr8_+_120289735 10.411 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr15_-_53996597 10.395 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr11_-_117640078 10.080


chr3_+_30623376 10.032 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr7_-_42243142 10.017 NM_000168
GLI3
GLI family zinc finger 3
chr17_-_7434113 9.979 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr3_+_30622905 9.882 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr6_+_41712907 9.856 MDFI
MyoD family inhibitor
chr3_+_161877640 9.807 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr11_+_12265022 9.751 NM_032867
MICALCL
MICAL C-terminal like
chr18_+_54039818 9.692 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr21_-_35343065 9.604 RUNX1
runt-related transcription factor 1
chr11_-_117640196 9.570 MPZL2
myelin protein zero-like 2
chr20_-_1257782 9.544 SDCBP2
syndecan binding protein (syntenin) 2
chrX_-_19598912 9.526 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr5_+_145296313 9.510 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr13_+_77007809 9.509 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr2_-_166359016 9.471 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr7_-_42243318 9.418 GLI3
GLI family zinc finger 3
chr18_+_54039779 9.411 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_73170290 9.262 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr6_+_74462226 9.215 NM_001159587
NM_001159588
NM_133493
CD109


CD109 molecule


chr11_+_35596310 9.172 NM_014344
FJX1
four jointed box 1 (Drosophila)
chr11_-_117640407 9.148 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr20_-_1257809 8.991 NM_080489
SDCBP2
syndecan binding protein (syntenin) 2
chr6_+_74462485 8.991 CD109
CD109 molecule
chr18_+_54039730 8.984 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr19_-_43955984 8.854 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr6_-_116799548 8.806 LOC100287467
hypothetical LOC100287467
chr9_-_116920232 8.686 NM_002160
TNC
tenascin C
chr18_+_59788242 8.620 NM_001031848
NM_002640
NM_198833
SERPINB8


serpin peptidase inhibitor, clade B (ovalbumin), member 8


chr6_+_12398514 8.573 NM_001168319
NM_001955
EDN1

endothelin 1

chr11_-_47502115 8.554 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr1_+_44171578 8.510 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr11_-_2907169 8.445 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr17_-_36928604 8.370 NM_002275
KRT15
keratin 15
chr15_+_38318528 8.327 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr19_-_3920736 8.304 NM_001348
DAPK3
death-associated protein kinase 3
chr1_-_150276064 8.302 S100A11
S100 calcium binding protein A11
chr12_-_51912101 8.228 NM_000966
RARG
retinoic acid receptor, gamma
chr3_-_31997738 8.197 OSBPL10
oxysterol binding protein-like 10
chr15_+_38849450 8.174 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr19_-_56215084 8.149 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr16_-_21221872 8.131 NM_001014444
NM_001888
CRYM

crystallin, mu

chr5_+_35892747 8.118 NM_002185
IL7R
interleukin 7 receptor
chr5_-_1935764 8.080 NM_016358
IRX4
iroquois homeobox 4
chr1_-_150276114 8.038 NM_005620
S100A11
S100 calcium binding protein A11
chr15_-_58477407 8.036 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr4_+_35959638 7.965 NM_001136536
DTHD1
death domain containing 1
chr18_+_59705918 7.951 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr17_-_36469869 7.943 NM_001165252
LOC730755
keratin associated protein 2-4-like
chr21_-_35181956 7.920 RUNX1
runt-related transcription factor 1
chr11_-_33701073 7.846 NM_001127227
CD59
CD59 molecule, complement regulatory protein
chr20_+_33223434 7.823 NM_006404
PROCR
protein C receptor, endothelial
chr11_+_20005704 7.819 NAV2
neuron navigator 2
chr19_-_48866111 7.759 NM_001005376
NM_001005377
NM_002659
PLAUR


plasminogen activator, urokinase receptor


chr16_+_55199978 7.611 NM_005953
MT2A
metallothionein 2A
chr10_+_123862430 7.599 TACC2
transforming, acidic coiled-coil containing protein 2
chr7_+_1543644 7.538 MAFK
v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
chr17_-_3407780 7.455 TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr17_-_37196463 7.452 NM_002230
NM_021991
JUP

junction plakoglobin

chr14_+_95792299 7.419 NM_000710
BDKRB1
bradykinin receptor B1
chr13_-_29321599 7.407 UBL3
ubiquitin-like 3
chr22_-_30388165 7.404 PISD
phosphatidylserine decarboxylase
chr1_+_28637247 7.309 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr14_+_62740878 7.290 NM_020663
RHOJ
ras homolog gene family, member J
chr6_-_112033775 7.265 TRAF3IP2
TRAF3 interacting protein 2
chr17_-_24068759 7.258 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr15_+_65205107 7.230 NM_001145102
SMAD3
SMAD family member 3
chr3_+_48482213 7.158 NM_016381
NM_033629
TREX1

three prime repair exonuclease 1

chr5_+_73145098 7.149 RGNEF
190 kDa guanine nucleotide exchange factor
chr1_-_151804929 7.130 NM_005978
S100A2
S100 calcium binding protein A2
chr11_-_8695974 7.090 ST5
suppression of tumorigenicity 5
chr6_-_112033752 7.082 TRAF3IP2
TRAF3 interacting protein 2
chr3_-_123995216 6.947 NM_024610
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr5_+_36642424 6.854 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr11_-_118286822 6.817 NM_182557
BCL9L
B-cell CLL/lymphoma 9-like
chr6_+_74462630 6.792 CD109
CD109 molecule
chr11_-_66898223 6.746 NM_001166212
CLCF1
cardiotrophin-like cytokine factor 1
chr17_+_71229110 6.707 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr9_-_109291866 6.696 NM_004235
KLF4
Kruppel-like factor 4 (gut)
chr12_-_15706340 6.673 EPS8
epidermal growth factor receptor pathway substrate 8
chr5_-_148422799 6.670 NM_024577
SH3TC2
SH3 domain and tetratricopeptide repeats 2
chr3_-_31998241 6.643 NM_001174060
NM_017784
OSBPL10

oxysterol binding protein-like 10

chr3_+_31998269 6.627 NM_001137674
ZNF860
zinc finger protein 860
chr1_-_89261021 6.552 NM_018284
GBP3
guanylate binding protein 3
chr14_+_20537253 6.534 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr11_+_58146721 6.519 NM_000614
CNTF
ciliary neurotrophic factor
chr17_-_3408038 6.503 NM_145068
TRPV3
transient receptor potential cation channel, subfamily V, member 3
chr7_-_16811131 6.469 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr1_+_40508336 6.466 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr1_+_35019376 6.359 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chr4_-_152366970 6.351 NM_001009555
NM_001128923
SH3D19

SH3 domain containing 19

chr9_-_34652629 6.343 NM_006664
CCL27
chemokine (C-C motif) ligand 27
chr3_-_127258299 6.316 NM_001008487
SLC41A3
solute carrier family 41, member 3
chr17_+_71229151 6.291 ITGB4
integrin, beta 4
chr6_+_83129641 6.278 NM_006670
TPBG
trophoblast glycoprotein
chr15_+_38923470 6.273 NM_003710
NM_181642
SPINT1

serine peptidase inhibitor, Kunitz type 1

chr18_-_45630154 6.266 MYO5B
myosin VB
chr3_+_69216747 6.263 NM_006407
ARL6IP5
ADP-ribosylation-like factor 6 interacting protein 5
chr18_-_26996742 6.199 NM_004948
NM_024421
DSC1

desmocollin 1

chr6_+_1556543 6.196 FOXC1
forkhead box C1
chr6_-_35804337 6.109 NM_001145775
FKBP5
FK506 binding protein 5
chr11_-_101906640 6.106 NM_002423
MMP7
matrix metallopeptidase 7 (matrilysin, uterine)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.68 2.41e-04 GO:0051246 regulation of protein metabolic process
1.68 2.18e-03 GO:0009611 response to wounding
9.82 3.10e-03 GO:0031581 hemidesmosome assembly
1.69 3.43e-03 GO:0009888 tissue development
2.00 6.21e-03 GO:0043086 negative regulation of catalytic activity
1.60 9.61e-03 GO:0032268 regulation of cellular protein metabolic process
1.68 1.29e-02 GO:0031399 regulation of protein modification process
7.72 2.71e-02 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
1.76 3.29e-02 GO:0042060 wound healing
1.73 3.48e-02 GO:0001932 regulation of protein phosphorylation
2.36 3.67e-02 GO:0008544 epidermis development
1.70 4.02e-02 GO:0042325 regulation of phosphorylation
1.57 4.47e-02 GO:0042127 regulation of cell proliferation
1.28 4.66e-02 GO:0048856 anatomical structure development

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.68 3.38e-03 GO:0000502 proteasome complex
1.13 1.50e-02 GO:0005737 cytoplasm
1.56 1.94e-02 GO:0005626 insoluble fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.62 3.37e-03 GO:0061135 endopeptidase regulator activity
2.59 4.30e-03 GO:0030414 peptidase inhibitor activity
2.63 5.00e-03 GO:0004866 endopeptidase inhibitor activity
2.34 1.42e-02 GO:0061134 peptidase regulator activity
2.03 2.56e-02 GO:0004857 enzyme inhibitor activity
1.14 4.24e-02 GO:0005515 protein binding